November 18, 2023

How Long Does Methadone Stay in Urine?

Methadone is a powerful tool for addiction treatment. It can help people struggling with opioid addiction by relieving withdrawal symptoms and curbing cravings for other opioids. It also blocks the pleasure-inducing effects of opioids when used appropriately. But because it is an opioid, it can show up in standard drug tests. Understanding how long methadone stays in urine can help individuals who are prescribed this medication pass those tests.

Usually, the liver helps break down methadone through a process called N-demethylation. This process removes one carbon and three hydrogen atoms from methadone. The result is the breakdown product EDDP, which can be found in a person’s blood and urine for days after they use the drug. The duration of how long methadone remains in a person’s system depends on their medical history, their reason for taking the drug, and their body chemistry.

Some factors that can impact how long a person’s methadone lasts in their system include age, body weight, and metabolism. Younger people tend to metabolize drugs faster than older adults. They are also more likely to pass drug tests sooner. People with a higher body weight are more likely to have more methadone in their bodies, which can last longer than someone of a healthy weight. Methadone and its metabolites are excreted from the body via urine and can be detected in urine, blood, saliva, and hair drug tests.

Urine tests are the favored method for testing for methadone because they are easy to administer, cheap, and non-invasive. They typically provide a detection window of up to two weeks after a person has used the drug. Blood and saliva tests are less favored because they require an invasive procedure to obtain a sample, and they have a much shorter detection window than urine tests.


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