May 26, 2024

Flexeril Dosage: Key Guidelines for Safe Use

Proper use of medications is critical to ensuring their effectiveness and minimizing the risk of adverse effects. One such medication is Cyclobenzaprine, commonly used under brand names like Flexeril, Amrix, and Fexmid. This muscle relaxant is typically prescribed for the short-term relief of muscle spasms and discomfort associated with acute musculoskeletal conditions.

Dosage Information

It's essential to follow the prescribed dosage instructions for Cyclobenzaprine, as these can vary based on individual medical conditions and age. For most adults, the recommended dose is 5 mg taken three times a day. Depending on the patient's response, the dose can be increased to 7.5-10 mg. For immediate-release tablets, the dosage for adults can range from 5 mg taken every 8 hours, whereas extended-release capsules come in 15 mg and 30 mg doses and are typically taken once daily. Cyclobenzaprine should generally not be prescribed for more than 2-3 weeks.

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Proper administration of Cyclobenzaprine is crucial for its effectiveness. Extended-release capsules should not be crushed or chewed to avoid increased side effects. If swallowing capsules is problematic, the medication may be mixed with a small amount of food, but any remaining mixture should not be saved for future use. It's always advisable to follow specific guidelines provided by healthcare professionals.

Missed Dose

If a dose is missed, take it as soon as possible. However, if it is close to the time for the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to make up for the missed one, as this can increase the risk of severe side effects.


Cyclobenzaprine should be stored in a closed container at room temperature, away from heat, moisture, and direct light. Always keep medications out of reach of children and dispose of any unused medicines properly to avoid accidental ingestion.

Healthcare Professional Guidance

Consulting with a healthcare professional for proper dosage determination and administration is crucial, especially for children and individuals with certain medical conditions. Patients with hepatic impairment or the elderly may require adjusted dosing due to increased plasma concentrations and prolonged drug half-life.

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Side Effects and Interactions

Common side effects include drowsiness, dizziness, dry mouth, constipation, and tiredness. It's important to inform your doctor if these side effects persist or worsen. Serious side effects such as fast/irregular heartbeat, mental/mood changes, and difficulties urinating should be reported immediately. Rare allergic reactions include rash, swelling, and breathing difficulties. Cyclobenzaprine can interact with other medications like MAOIs, benzodiazepines, and antidepressants, increasing the risk of adverse reactions.

Warnings and Precautions

Cyclobenzaprine is contraindicated in patients with hypersensitivity to any of its components and should not be used within 14 days of taking MAO inhibitors. Patients with a history of heart conditions or who are in the acute recovery phase of myocardial infarction should use caution. The risk of serotonin syndrome, heart arrhythmias, and central nervous system effects like dizziness and drowsiness should also be considered.

Category Details
Medication Name Cyclobenzaprine (Flexeril, Amrix, Fexmid)
Recommended Dosage
  • Immediate-release tablets: 5 mg every 8 hours for adults, can increase to 7.5-10 mg.
  • Extended-release capsules: 15 mg to 30 mg once daily for adults.
  • Not generally prescribed for more than 2-3 weeks.
  • Do not crush or chew extended-release capsules.
  • Capsules may be mixed with food if swallowing is difficult, but do not save the mixture.
Missed Dose Take as soon as possible. If close to the next dose, skip the missed dose. Do not double the dose.
  • Store at room temperature in a closed container.
  • Keep away from heat, moisture, and direct light.
  • Keep out of reach of children.
Common Side Effects
  • Drowsiness
  • Dizziness
  • Dry mouth
  • Constipation
  • Tiredness
Serious Side Effects
  • Fast/irregular heartbeat
  • Mental/mood changes
  • Difficulty urinating
  • Allergic reactions (rash, swelling, breathing difficulties)
Drug Interactions
  • MAOIs
  • Benzodiazepines
  • Antidepressants
Warnings and Precautions
  • Contraindicated in patients with hypersensitivity to components.
  • Avoid within 14 days of MAO inhibitors.
  • Use caution with heart conditions and during acute recovery from myocardial infarction.
  • Risk of serotonin syndrome, heart arrhythmias, and CNS effects like dizziness and drowsiness.
Healthcare Professional Guidance Consult a healthcare professional for proper dosage, especially for children, elderly, and individuals with hepatic impairment.

In summary, proper use of Cyclobenzaprine involves adherence to prescribed dosages and guidelines, careful consideration of side effects and interactions, and consultations with healthcare providers for personalized recommendations. By following these steps, patients can safely and effectively benefit from this medication for muscle spasm relief.

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